Nsaids Case

Background: NSAIDs is an anti-inflammatory drugs used in worldwide. However, there are some new incidence of serious side effect that is cardiovascular events.

Results: Due to many studies about NSAIDs associated with cardiovascular events, selective COX-2 inhibitors or coxibs were the highest cardiovascular risks, ibuprofen and diclofinac had higher risks of cardiovascular events than other conventional NSAIDs. In addition, naproxen was found that had more cardiovascular safety than others for long-term used.

This review discusses how NSAIDs can induce cardiovascular events, determines cardiovascular risks from NSAIDs usage by comparing among each specific NSAIDs and, provides the specific NSAIDs that have more cardiovascular safety than others for long-term use. NSAIDs are associated with cardiovascular risks via inhibition of COX-2 generating prostacyclin, a vasodilator and an anti-platelet aggregator. The relationship between NSAIDs and cardiovascular disease is more complex than initially thought even within groups of NSAIDs. Furthermore, the dose is possible to be important factor in defining cardiovascular safety. To our knowledge, etoricoxib, selective COX-2 inhibitor is the highest cardiovascular risks, and ibuprofen and diclofinac have higher risks of cardiovascular events than other conventional NSAIDs. Besides, it seems likely that naproxen have more cardiovascular safety than others for long-term use. The generalizability of our findings might be restricted because the articles reviewed did not study in Asia, so further studies should investigate this association in the Asian patients. These are so important, especially in patients with recent history of cardiovascular disease and have musculoskeletal symptoms that are frequently treated with NSAIDs. Therefore, the health care providers need to carefully consider whether an NSAID is really necessary. If such therapy is thought unavoidable then it should be used in the lowest possible